منابع مشابه
Nociceptors Are Interleukin-1 Sensors
Alexander M. Binshtok,1 Haibin Wang,1 Katharina Zimmermann,2 Fumimasa Amaya,1 Daniel Vardeh,1 Lin Shi,1 Gary J. Brenner,1 Ru-Rong Ji,3 Bruce P. Bean,4 Clifford J. Woolf,1 and Tarek A. Samad1,5 1Neural Plasticity Research Group, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, 2Department of Cardiology, Howard Hughes Medical Institute, and Department o...
متن کاملNociceptors: the sensors of the pain pathway.
Specialized peripheral sensory neurons known as nociceptors alert us to potentially damaging stimuli at the skin by detecting extremes in temperature and pressure and injury-related chemicals, and transducing these stimuli into long-ranging electrical signals that are relayed to higher brain centers. The activation of functionally distinct cutaneous nociceptor populations and the processing of ...
متن کاملAmiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors.
Many painful inflammatory and ischemic conditions such as rheumatoid arthritis, cardiac ischemia, and exhausted skeletal muscles are accompanied by local tissue acidosis. In such acidotic states, extracellular protons provoke the pain by opening cation channels in nociceptors. It is generally believed that a vanilloid receptor subtype-1 (VR1) and an acid-sensing ion channel (ASIC) mediate the g...
متن کاملSensitisation of Nociceptors – What are Ion Channels Doing?
Nociceptors are peripheral sensory neurones which respond to painful (noxious) stimuli. The terminals of nociceptors, which have a high threshold to stimulation in their native state, undergo a process known as sensitisation, or lowering of threshold, following injury or inflammation. Amongst sensory receptors, sensitisation is a property unique to nociceptors. A shift in the stimulus-response ...
متن کاملMechano-insensitive nociceptors are sufficient to induce histamine-induced itch.
The nerve fibres underlying histamine-induced itch have not been fully elucidated. We blocked the lateral femoral cutaneous nerve and mapped the skin area unresponsive to mechanical stimulation, but still sensitive to electrically induced pain. Nerve block induced significantly larger anaesthetic areas to mechanical (100 mN pin-prick, 402 ± 61 cm²; brush, 393 ± 63 cm²) and heat pain stimuli (40...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2008
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.3795-08.2008